Brainstem-based toolkit and biomarkers of prodromal Parkinson’s disease

The project develops a publicly available Brainstem Navigator toolkit to locate small brainstem nuclei automatically in conventional patient MRI scans. The toolkit will be applied to data from the Parkinson’s Progression Markers Initiative to derive markers of prodromal Parkinson’s disease. Analyses will examine both differences between participants and changes over time, supporting the search for brainstem measures that can characterise disease before its established clinical presentation.